NFKB1 and amyotrophic lateral sclerosis: It has been found that NF-kB, a key regulator of inflammation, is upregulated in the spinal cords of ALS patients and mSOD1G93A mice; however, NF-kB inhibition wasn’t enough to save MNs, while the deletion of NF-kB signalling in microglia successfully rescued MNs from microglial-mediated death in vitro and extended survival in ALS mice by reducing pro-inflammatory activation.