ATXN2 and Cognitive impairment: SCA1, SCA2, and SCA3 (Machado–Joseph disease) are characterized by progressive gait ataxia with pyramidal and/or extrapyramidal features, with cognitive impairment in SCA1 and slow saccades in SCA2 as characteristic features [2,3,7,8,9,10]; SCA3, first described among Portuguese emigrants to Massachusetts [11], up to date, remains the most prevalent SCA globally [1].