miR-652-5p downregulation promotes tumor aggressiveness via hypermethylation of its promoter and activation of the SDC1/TGFβ2/pERBB4 axis under hypoxic conditions [202]; miR-7-2-3p acts as a tumor suppressor by targeting DCLK1, thereby modulating the PI3K/Akt/NF-κB pathway and limiting proliferation, EMT, and metastatic potential [203]. This evidence concerns the gene AKT1 and neoplasm.