PDK1 and neoplasm: These four miRNAs influence key oncogenic and tumor-suppressive pathways, including the CDH1, p21, Bim, PDK1, IGF1R, MXI1 and JAK2 pathways, which regulate cell cycle progression, apoptosis, proliferation, metabolic adaptation, clonogenicity, invasion, and metastatic potential, making them promising panels for EAC screening [185].