miR-655, which is implicated in EMT regulation and ESCC prognosis [151], is markedly downregulated in ESCC cells and tissues, and its overexpression increases E-cadherin levels by directly targeting ZEB1 and TGFBR2, thereby significantly inhibiting cell migration and invasion [152]. This evidence concerns the gene TGFBR2 and esophageal squamous cell carcinoma.