EGF and neoplasm: Other circulating miRNAs upregulated in ESCC include miR-25 [61], which supports tumor progression by repressing several tumor-suppressor genes and activating the TGF-β, VEGFA/VEGFR, EGF/EGFR, and Wnt/β-catenin signaling pathways, which are fundamental for angiogenesis and metastasis [62].