These include GAK (cyclin G-associated kinase), which is involved in clathrin-mediated membrane trafficking [111]; PRKCI, whose repression impairs proliferation, clonogenicity, and cancer stem–like properties via the suppression of Hedgehog signaling [113]; and components of the JAK2/STAT3 pathway, resulting in reduced vimentin expression and invasive capacity [112]. This evidence concerns the gene GAK and cancer.