ACHE and early-onset autosomal dominant Alzheimer disease: Cholinesterase (ChE) enzyme family, consisting of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), play a significant role in the pathology of Alzheimer’s disease (AD) due to their involvement in acetylcholine (ACh) breakdown, a crucial neurotransmitter for memory and learning.