MM cells exploit their bone marrow niche by interacting with mesenchymal stromal cells (MSCs), which promote the activation of several pro-survival signaling cascades—including IL-6/JAK/STAT, PI3K/AKT, NF-κB, and MAPK/ERK—contributing to drug resistance, immunoevasion, and proliferation [83]. Here, AKT1 is linked to Miyoshi myopathy.