Mechanistically, RNA-based therapeutics MALAT1 activates the EZH2/STAT3 axis, modulates the HIF-1α-KDM3A pathway under hypoxia [159], interacts with FAM46C to drive migration [161], and sponges tumor-suppressive miRNAs such as miR-125b, miR-1271-5p, miR-509-5p, miR-188-5p, and miR-15a/16 [158,162,163,164]. The gene discussed is HIF1A; the disease is neoplasm.