Elevated HOTAIR levels are also observed in MM patients with bisphosphonate-induced osteonecrosis of the jaw (BRONJ), linking HOTAIR to bone pathology [172] (see Supplementary Tables S3 and S4, which detail HOTAIR’s mechanisms in NF-κB/JAK-STAT activation, glucocorticoid resistance, bone pathology, and exosomal transfer, together with key experimental and clinical correlations that reinforce its therapeutic and prognostic relevance). This evidence concerns the gene NFKB1 and Miyoshi myopathy.