TNF and Miyoshi myopathy: In vitro, Descartes-08 achieved 66–82% lysis of CD138+ primary MM cells and robust cytotoxicity against MM cell lines (MM1S, RPMI-8226, H929), including lenalidomide- and pomalidomide-resistant variants, with strong IFN-γ, TNF-α, and IL-2 secretion (Table 5).