MYC and Miyoshi myopathy: Genetic alterations driving multiple myeloma (MM) include primary events like hyperdiploidy and recurrent translocations (e.g., t(11;14), t(4;14), t(14;16)), which initiate disease development, and secondary events, such as 1q gain, 13q and 17p deletions, and MYC translocations (t(18;14)), that contribute to progression and poor prognosis [71].