Tumor-suppressive miRNAs, such as miR-125b and miR-509-5p, are sequestered by long non-coding RNAs (lncRNAs), like MALAT1 and HOTAIR, which act as competing endogenous RNAs (ceRNAs), enhancing oncogenic signaling [158,162,172,193]. The gene discussed is HOTAIR; the disease is neoplasm.