AURKA and neoplasm: Other tumor-suppressive miRNAs, including miR-15a, f, and miR-34a, target BCL2 and AURKA to promote apoptosis and inhibit proliferation, while oncogenic miRNAs (oncomiRs) like miR-21 and miR-221/222 drive drug resistance by targeting PTEN and other pathways [208,209,210,211,212].