For example, co-cultivation of TIM-3-overexpressing macrophages with intestinal lymphocytes reduced the proinflammatory response in a mouse model of colitis [48], and blocking TIM-3 on peritoneal macrophages resulted in a decrease in Tregs but an increase in Th1 and Th17 CD4+ T cells [51]. The gene discussed is HAVCR2; the disease is colitis.