Our initial explorations into the realm of condensatopathies have been largely guided by prominent examples, particularly the roles of proteins like TDP-43, FUS, and Tau in devastating neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), and Alzheimer’s Disease (AD). Here, TARDBP is linked to Alzheimer disease.