At the tissue level, CRC specimens frequently exhibit heightened intracellular Mg2+ compared with adjacent normal mucosa [6,7], likely driven by increased uptake through Transient Receptor Potential Melastatin (TRPM)6, TRPM7, and Magnesium Transporter 1 (MagT1), coupled with reduced efflux via Cyclin M4 (CNNM4) [8,9,10,11]. The gene discussed is TRPM6; the disease is colorectal carcinoma.