In cancer, activated dendritic cells trigger naïve T cells through the T cell receptor to release TGF-β and IL-6, which activate Th17 [78] to release IL-23 that binds IL-23R and, in an autocrine loop manner, stimulates effector or memory Th17 cells to secrete IL-17, IL-17F, and IL-22 [79]. The gene discussed is IL37; the disease is cancer.