An additional mechanistic network was derived from the INDRA database, revealing key protein interactions involving DNMT3B (Figure 4b), followed by functional enrichment analysis using the Enrichr database, which supported these findings, highlighting the involvement of NANOG and OCT4 -key regulators of cancer stemness- as top overlapping genes with DNMT3B (Figure 4c,d). The gene discussed is DNMT3B; the disease is cancer.