In the combined cohort, upon induction of hypoglycemia, there were significant decreases in cadherin-5 (p = 0.01) (Figure 1B) and sTie-2 (p = 0.01) (Figure 1G) and significant increases in P-selectin (p < 0.01) (Figure 1C), PAI-1 (p < 0.001) (Figure 1H), ANGPT1 (p < 0.001) (Figure 1F) and ICAM3 (p = 0.03) (Figure 1D) compared to baseline. Here, ICAM3 is linked to Hypoglycemia.