In the combined cohort, there were significant decreases in cadherin-5 (p = 0.01) (Figure 1B) and ICAM5 (p < 0.01) (Figure 1E) at 2 h and in PAI-1 (p = 0.02) (Figure 1H) at 4 h post hypoglycemia in both T2D and controls compared to baseline. This evidence concerns the gene CDH5 and type 2 diabetes mellitus.