The most notable findings in terms of differences between the diabetes and control groups over time include significant decreases in E-selectin, ICAM3 and P-selectin at 2 h post hypoglycemia in the T2D group compared to the control group, as well as decreases in PAI-1 at 4 h and ICAM3 at 24 h post hypoglycemia in the T2D group compared to the control group. This evidence concerns the gene SERPINE1 and type 2 diabetes mellitus.