We observed significant baseline differences between groups for several proteins with higher E-selectin, P-selectin, ANGPT1 and PAI-1 and reduced cadherin-5 in T2D, which may suggest inflammatory endothelial activation leading to a pro-thrombotic, destabilized vascular phenotype characteristic of diabetic vasculopathy. The gene discussed is CDH5; the disease is type 2 diabetes mellitus.