In this study, hypoglycemia did not result in changes in VEGFA, ICAM1, ICAM2 and VCAM1 as known mediators of endothelial dysfunction associated with atherosclerosis, stroke and myocardial infarction [40,41,42], as well as T2D microvascular complications [43]. This evidence concerns the gene ICAM2 and myocardial infarction.