All proteins that differed at baseline and/or during the hypoglycemia time course are visualized in Figure 2A, whilst only the proteins that differed between T2D and controls at baseline are shown in Figure 2B. Gene ontology (GO) and pathway synthesis showed three tightly coupled functional axes—namely, E-selectin, ICAM3 and ICAM5 for endothelial activation and leukocyte adhesion; P-selectin and vWF for platelet adhesion; and ANGPT1 and PAI-1 for angiopoietin fibrinolytic balance. This evidence concerns the gene ICAM5 and type 2 diabetes mellitus.