Overall, cadherin-5 and sTie-2, together with increases in P-selectin, ICAM3, ANGPT1 and PAI-1, suggest that hypoglycemia may result in a shift from endothelial stability to an inflammatory, pro-adhesive and pro-thrombotic phenotype, indicating worsening endothelial dysfunction after baseline. The gene discussed is SERPINE1; the disease is endothelial dysfunction.