Several proteins exhibited significant changes over time compared to baseline, particularly under hypoglycemia (cadherin-5 and sTie-2 showed decreases, while P-selectin, ICAM3, ANGPT1 and PAI-1 showed increases compared to baseline) and in the subsequent hours post hypoglycemia (an increase at 30 min, 1 h and 24 h for P-selectin; a decrease at 2 h for ICAM5; a decrease at 4 h for PAI-1; an increase at 24 h for ICAM3; and a decrease at 2 h for Cadherin-5). The gene discussed is SERPINE1; the disease is Hypoglycemia.