These receptors, which include GPCRs, cytokine receptors, and Toll-like receptors (TLRs), facilitate the opening of ion channels, particularly TRP channels like TRPV1 and TRPA1, and mediate receptor-operated calcium entry (ROCE), leading to the generation of pruritus action potentials [46] (Table 1 and Figure 2). The gene discussed is TRPA1; the disease is Pruritus.