MUC5AC and cystic fibrosis: Despite considerable methodological heterogeneity across prior studies, CF gut dysbiosis was characterized by delayed microbial maturation, and alteration in microbial functionalities such as enrichment of mucin/glycan degradation, enhancement of xenobiotic and antibiotic-associated pathways, increased Staphylococcus aureus infection modules, alteration in glycosphingolipid metabolism, and attenuation of short-chain-fatty-acid pathways [9,14,25,41].