IL6 and periodontitis: The principal findings were that both cortisone and cortisol were significantly elevated in patients with Stage III/IV periodontitis compared with Stage I/II, and that cortisone demonstrated consistent associations with pro-inflammatory cytokine IL-6 and clinical periodontal parameters—FMPS, PPD > 5 mm, CAL ≥ 5 mm, BoP, and BL/Age ratio.