Pilot study in Santo André, Brazil (n = 14; periodontitis group n = 7 [4 M/3 F], stages I–III; healthy controls n = 7 [4 M/3 F]); power > 98% at α = 0.05. Pro-inflammatory cytokines, e.g., IL-5 and IL-6, in gingival crevicular fluid were reduced post-treatment to levels comparable to healthy controls.Treatment was safe, well-tolerated, and showed potential for periodontal regeneration. Here, IL5 is linked to periodontitis.