CD4 and diabetes mellitus: These data are in agreement with a previous work showing that highly diabetogenic CD4+ T cells from TCRαβ transgenic 4.1-NOD mice can cause diabetes in the absence of CD8+ T cells, as demonstrated by full diabetes onset in 4.1-NOD.RAG2−/− mice and full development of diabetes in TCRαβ transgenic 8.3-NOD mice and reduction in diabetes by 50% in 8.3-NOD RAG2−/− [14,15].