After adjusted for age, sex, hypertension, diabetes, and hyperlipidemia, and were corrected for multiple testing using the BH-FDR method, the risk of HLA-C*08:01, DQA1*01:05, DQA1*03:01, DQA1*03:03, DQB1*03:02, DQB1*04:01, DRB1*04:03, DRB1*04:05, and DRB1*10:01 were significantly higher in patients with IgAN than in controls. The gene discussed is HLA-C; the disease is Hypertension.