FNDC5 and type 2 diabetes mellitus: A two-way ANOVA (Kruskal–Wallis) test was used to evaluate the effects of the HTGW phenotype (column factor: NTEW, ETNW, HTGW) and marker type (row factor: insulin, HOMA-IR, QUICKI, TG/HDL-C, AIP, LAP, irisin) in patients with PreDM and T2DM (Table 3).