The group of Landmesser generated iPSCs from lifestyle-matched donors stratified by cardiovascular risk (older healthy individuals, patients with stable coronary artery disease, and younger patients with acute coronary syndrome) and differentiated them into ECs, which were then stimulated with TNF-α to mimic an inflammatory state under static, atheroprotective, and atheroprone flow conditions. The gene discussed is TNF; the disease is acute coronary syndrome.