The patient-specific organoids developed abnormally dilated, leaky vascular structures resembling cavernomas, and the iPSC-derived ECs showed alterations in the expression of genes such as KLF2, KLF4, CAV1, ADAMTS4, and vWF, as well as cell junctional defects, resulting in reduced trans-endothelial electrical resistance. This evidence concerns the gene ADAMTS4 and cavernous hemangioma.