LGR5 and Chronic colitis: Given that mucosal regeneration and MALT development are associated with chronic colitis, we examined correlations among several histopathological and immunohistochemical parameters in Experiment I. The association between positive cell rates of Ki-67 and LGR5 was determined by the Spearman’s correlation coefficients, which were very strong for each parameter (correlation coefficient rs = 0.84, p < 0.01) (Figure 4A,B; Supplemental Table S7 and Figure S8).