In our earlier studies, we have demonstrated the potential of triterpenoid compounds (betulinic acid and maslinic acid) to modulate nutrient-sensing signaling networks such as the phosphoinositide 3 kinase (PI3K)/protein kinase B (AKT) signaling in both in vitro and in vivo models of obesity [10,20,41]. Here, AKT1 is linked to obesity due to melanocortin 4 receptor deficiency.