MGMT and glioblastoma: As depicted in Table 1 and Figure 1E, the distribution of promoter methylation patterns across the two groups showed that the NND group had a substantially greater median [IQR] of MGMT promoter methylation (98.00 [97.00, 100.00]) than the GBM group (66.00 [13.00, 97.00]) (p < 0.001, Mann–Whitney U test).