GLI1 has been demonstrated to increase GBM cell proliferation, survival, angiogenesis, and stemness through regulation of target genes, including B-cell leukemia/lymphoma 2 protein (BCL2), vascular endothelial growth factor (VEGF), and sex-determining region Y-box 2 (SOX2) [34]. This evidence concerns the gene SOX2 and glioblastoma.