GLI1 and glioblastoma: Univariate logistic regression analysis identified promoter methylation levels of the NUPR1, NDRG2, GLI1 genes, as well as age, as significant predictors of GBM disease (p < 0.05), as shown in Table 7, However, in multivariate analysis adjusted for covariates, only promoter methylation of the NDRG2 gene remained a significant independent predictor of GBM disease (OR = 1.71, 95% CI (1.25–3.57), p = 0.028), as presented in Figure 7 and Table 8.