NUPR1 and neoplasm: In the univariate analysis, the multiple tumor site was significantly associated with a higher risk of mortality (HR = 4.44, 95% CI = 1.42–13.88, p = 0.010), whereas NUPR1 promoter hypermethylation was significantly associated with a lower risk of mortality (HR = 0.97, 95% confidence interval [CI] = 0.96–0.99, p = 0.002).