Significantly upmodulated genes also included Hepatocyte Growth Factor (HGF), having a significant role in the progression and metastasis of melanoma by promoting tumor cell survival, proliferation, and migration [38,39], Cytotoxic T-Lymphocyte Associated Protein 4 (CTLA4), Wingless-Type MMTV Integration Site Family, Member 10B (WNT10b), Baculoviral IAP Repeat Containing 5 (also known as Survivin BIRC5), Dickkopf WNT Signaling Pathway Inhibitor 2 (DKK2), Vascular Endothelial Growth Factor (VEGF), Bone Morphogenetic Protein 2 (BMP2), Colony Stimulating Factor 1 (CSF1) and Cyclin B1 (CCNB1). The gene discussed is DKK2; the disease is neoplasm.