MRGPRX1 and irritable bowel syndrome: Dietary factors are major modulators of IBS symptoms and pathophysiology; structured interventions—most notably the low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet—reduce global symptoms, bloating and abdominal pain in many patients, likely by decreasing luminal fermentation, modifying microbiota-derived metabolites and downstream GPCR-mediated signaling [39,40].