COL1A1 and osteogenesis imperfecta: In particular, due to its genetic similarity to humans and rapid development, the zebrafish (Dario renio) has emerged as a valuable model that well recapitulates both the skeletal and extraskeletal features of OI; specifically, the chihuahua (Chi/+) COL1A1 mutant is one of the most extensively studied zebrafish models and is frequently employed in OI drug screening [33].