TP53 and cancer: Additionally, in this study, TP53, which is similar to other cancer genes such as PTEN and SMARCA4, exhibits many interactions with other genes within the network of the “common EBL-related cluster.” Moreover, this cluster appears to represent a potential serve as a missing link between several genes that we previously reported as EBL-related genes, including PRMT5, MSH2, EXO1, RTN4IP1, ATG5, RPTOR, and CHEK2 [23,24,31,32].