In addition, “Proteoglycans in cancer” was shared across “IS-Clustered genes.” These eight pathways comprised 23 genes (CREBBP, KRAS, EFNA5, HDAC4, IRS2, MTOR, NOTCH1, PTEN, PDGFRB, RPTOR, TP53, TIAM1, ANK3, CAMK2A, CAMK2D, ERBB4, MRAS, GNAI1, SKP2, AGTR1, MSH2, MSH3, MYD88) and 10 genes (EFNA5, HDAC4, PTEN, TIAM1, CAMK2A, CAMK2D, ERBB4, MRAS, GNAI1, and MSH3), which were “IS-Clustered genes” (Table 9, shown in bold). The gene discussed is NOTCH1; the disease is cancer.