Additionally, integration events within an intron of the checkpoint kinase 2 (CHEK2) gene and in the intergenic region of clarin 1 (CLRN1) and siah E3 ubiquitin protein ligase 2 (SIAH2) were observed at the onset of lymphoma in naturally infected BLV individuals who progressed from a premalignant stage to terminal disease [32]. Here, CHEK2 is linked to lymphoma.