Comparison between the reference genes in the OncoKBTM Cancer Gene List (https://www.oncokb.org/cancer-genes, accessed on 8 October 2025) and the 246 “IS-Related genes” clearly showed that only 17 genes (6.9%), namely IL10, BPHB1, ERBB4, HDAC4, ITK, MSH3, POT1, PRDM16, PTEN, SGK1, SMARCA4, TPR, CHN1, DPYD, LRRK2, MART1, and TBL1XR1, as shown in red in Table 1 among the 246 “IS-Related genes” cancer genes (Figure 3B and Table 1, shown in red). The gene discussed is TBL1XR1; the disease is cancer.