Thus, 38 “IS-Related genes” (CAMK2A, ERBB4, GHR, IL10, FBXL17, FBXO4, HECTD2, DTL, RNF144A, UBE3D, RNGTT, DUSP10, PTEN, PPM1A, PTPRM, LDB2, POU3F3, SMARCA4, TBL1XR1, TEAD1, TEF, CCDC32, HDAC4, HOXA2, RFX7, SLC30A9, TOX, TFAP2A, ZNF407, EPHB1, FER, ACAN, CNTNAP2, NECTIN4, PARVA, PCDH7, TINAG, and VCL) were associated with these five GO terms, and only 6 genes, such as ERBB4, IL10, SMARCA4, TBL1XR1, HDAC4 and EPHB1 were cancer genes. Here, POU3F3 is linked to cancer.