In addition, these “IS-Clustered genes” included 12 cancer genes (14.1%), namely CHN1, SGK1, IL10, PTEN, HDAC4, ERBB4, BPHB1, SMARCA4, TBL1XR1, ITK, MSH3 and POT1, as shown in red color in Figure 4. The gene discussed is ITK; the disease is cancer.