Similarly, 14 KEGG pathways, including “Dopaminergic synapse,” “PI3K-Akt signaling pathway,” “Amphetamine addiction,” “Long-term potentiation,” “Adrenergic signaling in cardiomyocytes,” “cAMP signaling pathway,” “Nucleotide metabolism,” “Axon guidance,” “Proteoglycans in cancer,” “Cholinergic synapse,” “Pyrimidine metabolism,” “Long-term depression,” “Calcium signaling pathway,” and “Cushing syndrome were identified in the same “IS-Clustered genes” and 35 KEGG pathways were newly detected. This evidence concerns the gene AKT1 and Cushing syndrome due to macronodular adrenal hyperplasia.