NOTCH1 and cancer: Furthermore, 14 cancer-related genes were identified (CREBBP, KRAS, HDAC4, IRS2, MTOR, NOTCH1, PTEN, PDGFRB, RPTOR, TP53, ERBB4, MSH2, MSH3, and MYD88) among these 23 genes (Table 9, shown in red).