Considering the pivotal role of the PI3K/AKT pathway and redox imbalance in NSCLC, these attributes provide a compelling reason to explore 2,3′-dihydroxy-5′-methoxystilbene as a potential AKT-targeting and redox-modulating agent in NSCLC cell lines. The gene discussed is PIK3CA; the disease is non-small cell lung carcinoma.