Taken together, the decrease in p-AKT and p-GSK3β, combined with selective apoptosis and ROS induction, supports a model in which 2,3′-dihydroxy-5′-methoxystilbene attenuates AKT signaling and perturbs redox homeostasis in susceptible NSCLC cells. The gene discussed is AKT1; the disease is non-small cell lung carcinoma.