Taken together, the decrease in p-AKT and p-GSK3β, combined with selective apoptosis and ROS induction, supports a model in which 2,3′-dihydroxy-5′-methoxystilbene attenuates AKT signaling and perturbs redox homeostasis in susceptible NSCLC cells. This evidence concerns the gene GSK3B and non-small cell lung carcinoma.