PIK3CA and non-small cell lung carcinoma: In summary, the integration of these references reinforces that the predicted and observed activities of 2,3′-dihydroxy-5′-methoxystilbene are mechanistically aligned with PI3K/AKT/GSK3β inhibition and its downstream regulation of proliferation, apoptosis, clonogenicity, and migration in non-small-cell lung cancer (NSCLC), consistent with the broader stilbene literature [30,36,38].