Computational mapping and docking studies predicted a selective target profile for 2,3′-dihydroxy-5′-methoxystilbene, revealing a 1.1% overlap across 101 NSCLC-associated proteins and clustering at high-degree hubs (HSP90AA1, HSP90AB1, ESR1, SRC, and PIK3CA) that are central to PI3K/AKT signaling and adaptive stress responses [34,35]. Here, ESR1 is linked to non-small cell lung carcinoma.