In the present study, although Cx43 remained stable, PKC-α-MAPK14-ADAM17 signaling is still overactive in the SGs, implying that other endogenous factors and post-translational modifications of Cx43 are involved in the activation of PKC-α-MAPK14-ADAM17 signaling in T2DM. The gene discussed is ADAM17; the disease is type 2 diabetes mellitus.