The reproducibility of the positive result, despite differences in the etiology of the models (polymicrobial sepsis versus immune-mediated inflammation) and delivery method (naked siRNA versus antibody-targeted conjugate), highlights the important role of BTK in the pathogenesis of ARDS and reinforces its value as a promising therapeutic target and suggests that the effect is not an artifact of a single experiment. This evidence concerns the gene BTK and acute respiratory distress syndrome.