Sterol O-acyltransferases 1 (SOAT1) [103], suppression of NAD(P)-dependent steroid dehydrogenase-like (NSDHL), and statins [104] also promote EMT by disturbing cholesterol metabolism in HCC and pancreatic mouse models with KrasG12D expression and homozygous Trp53 loss. The gene discussed is SOAT1; the disease is hepatocellular carcinoma.