Transmembrane protein 147 (TMEM147) upregulates DHCR7 via signal transducer and activator of transcription 2 (STAT2) in hepatocellular carcinoma (HCC), elevating 27HC and GPX4, which strengthens ferroptosis resistance and metastasis (Figure 3B) [93]. The gene discussed is GPX4; the disease is hepatocellular carcinoma.