Since VEGF is essential for maintaining vascular homeostasis and endothelial cell physiological function and signaling, a ‘VEGF-oriented’ perspective has been proposed for better elucidating the pathogenic mechanisms of PAH by using a new rodent model in which a VEGF receptor kinase antagonist may be instrumental in shedding light on the contribution of VEGF in the development of the disease [20,21]. This evidence concerns the gene VEGFA and pulmonary arterial hypertension.