STAT3 and cancer: Moreover, chronic inflammation and stress-induced hormonal signaling (e.g., β-adrenergic and glucocorticoid receptor pathways) converge on oncogenic transcription factors such as Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) and Signal Transducer and Activator of Transcription 3 (STAT3), creating a microenvironment conducive to both cellular senescence and cancer growth [17].