NOX4 and metabolic syndrome: In aortic tissue, none of the oxidative stress markers were modified either by MetS or by supplementation with CTE or BPL1® HT except for the mRNA levels of NOX-4 that were significantly increased in mice fed with the HFHS diet and normalized in mice supplemented with CTE or BPL1® HT both alone (p < 0.01) or in combination (p < 0.001) (Figure 9B).