MYC and leukemia: In our study, MYC’s contribution as an individual marker was strong, achieving the highest AUC for the discrimination between leukemia vs. non-leukemia samples (AUC = 0.835, Figure 5a), and second for leukemia + MRD-positive vs. non-leukemia + MRD-negative samples (AUC = 0.769, Figure 5b).