Genetic variants in desmosomal proteins (e.g., PKP2, DSP, DSG2, DSC2) are strongly associated with arrhythmogenic right ventricular cardiomyopathy (ARVC), while mutations in sarcomeric and cytoskeletal genes (e.g., MYH7, LMNA, DES) are linked to hypertrophic and dilated cardiomyopathies. Here, DSG2 is linked to arrhythmogenic right ventricular cardiomyopathy.