IL-10 also increases ACE2 expression, and a genetic risk factor has been identified: a polymorphism (rs13050728) dependent readthrough from IFNAR2 into the downstream IL-10 receptor gene, IL10RB, results in the formation of a hybrid receptor (CiDRE) that enhances IL-10 signaling while attenuating type I IFN signaling, thereby worsening COVID-19 severity [91]. This evidence concerns the gene IL10 and COVID-19.