Notably, cytokines such as TNF-α, IL-1β, IL-6, IFN-γ, and IL-10 not only amplify the production of additional cytokines—including themselves—but also play critical roles in regulating immune cell differentiation and function, thereby exacerbating immune dysregulation in severe COVID-19 [82,83,84,85,86,87]. This evidence concerns the gene IFNG and COVID-19.