AKT1 and colorectal carcinoma: Aggressive subtypes of human CRC frequently exhibit amplification of the c-myc gene [45]; NR4A1 has been linked to transcriptional programs that promote epithelial–mesenchymal plasticity and invasion [46,47], while SGK1 is a downstream effector of PI3K/AKT that contributes to resistance to stress and to maintenance of EMT states [48,49].