For this purpose, we chose the same tumor cell lines: Caco-2, quite differentiated and with a phenotype similar to that of enterocytes, characterized by strong barrier properties and a low basal inflammatory tone [17], and SW-620, derived from poorly differentiated metastatic adenocarcinomas, that exhibited higher activation of the NF-κB and STAT3 pathways [18]. The gene discussed is STAT3; the disease is adenocarcinoma.