In fact, SULF2 is involved in Wnt-driven tumor progression [33,34], PLAUR in extracellular matrix remodeling and migration [35,36], DUSP4 in sustaining epithelial–mesenchymal plasticity [37,38], and ATP6V0A4/V-ATPase-dependent acidification in invasive phenotypes [39]. The gene discussed is SULF2; the disease is neoplasm.