In addition, the CIBERSORT findings regarding elevated mast cells in high-risk patients, whereas the PPARG showed a specific affinity for cancer associated fibroblasts (R = 0.36) and macrophage M2, and was the unique driver associated with activated mast cells (R = 0.17), suggesting a stromal-mediated immune exclusion mechanism; In contrast, the proliferation-related genes PLK1 and AURKA were primarily associated with MDSC recruitment (R > 0.40). This evidence concerns the gene PLK1 and cancer.