We investigated the HPA immunohistochemistry and DepMap CRISPR screenings to confirm the tumor-intrinsic essentiality of PLK1 and AURKA, while utilizing the TISCH single-cell dataset to validate the microenvironmental specificity of CTLA4 (T-cells) and PPARG (CAFs/Macrophages) (Figure S9). Here, AURKA is linked to neoplasm.