AIF1 and amyotrophic lateral sclerosis: The results showed that the elevated level of Iba1 in microglial cells due to ALS pathology was reduced by approximately 23% following BMD-001S IV administration, compared to the vehicle-treated SOD1G93A transgenic mice with comparable disease severity (F(2,15) = 59.06, p < 0.0001) (Figure 5H,I).