An analysis of tumor-infiltrating lymphocytes (TILs) revealed that the effector function and exhaustion states were comparable between the two groups, as indicated by the similar levels of cytokine production (IFN-γ, TNF-α), cytolytic molecule expression (GZMB), and exhaustion marker expression (PD-1, TIM-3, LAG-3, TOX) (Figure 7H–M). Here, TNF is linked to neoplasm.