In another study including 9 individuals with T2DM, i.v. co-infusion of GIP with glucose to establish an IIGI condition (4 pmol/kg/min for 20 min followed by 2 pmol/kg/min for 30 min) similarly reduced plasma CTX concentrations without altering P1NP levels [101]. The gene discussed is CYP27A1; the disease is type 2 diabetes mellitus.