GIP and type 2 diabetes mellitus: Meanwhile, another trial involving 12 T2DM male patients examined the effects of i.v. GIP infusion (4 pmol/kg/min for 15 min followed by 2 pmol/kg/min for 75 min) under three different glycemic conditions: insulin-induced hypoglycemia, fasting hyperglycemia, and aggravated hyperglycemia.