GIP and type 1 diabetes mellitus: In a single-dose streptozotocin (STZ, 150 mg/kg)–induced diabetic mouse model mimicking human T1DM, daily i.p. administration of (D-Ala2)GIP (25 nmol/kg) for 21 days did not prevent reductions in whole-bone mechanical properties, such as ultimate load and stiffness, nor did it rescue cortical microstructure deterioration.