Given the established association of IRF5 with SLE in the Hispanic population and the close pathogenic relationship between SLE and pSS, our study aimed to determine whether four IRF5 SNVs (rs2004640G/T, rs2070197T/C, rs10954213G/A, and rs59110799G/T) are associated with pSS susceptibility in a Mexican population. The gene discussed is IRF5; the disease is systemic lupus erythematosus.