BUC metastasis is associated with hypoxia-induced EMT, and scutellarin can block this process through the inhibition of PI3K/Akt and MAPK signaling pathways, reducing the migration, invasion, and metastasis of BUCs in vivo, with minimal toxicity to normal cells, making it a promising therapeutic approach for targeting tumor metastasis [121]. This evidence concerns the gene AKT1 and neoplasm.