AKT1 and urinary bladder carcinoma: It is also important to note that no matter what kind of natural product it is, its regulation of bladder cancer survival and metabolism mainly occurs by regulating the MAPK family signal transduction pathway [42,62,63,78,94,95,96,97,113,121] and the PI3K/Akt/mTOR pathway [26,36,99,100,126].