To unravel the effect of MI14 on the signaling pathways involved in the development of cardiac hypertrophy, we examined phosphorylation levels of the hypertrophy-associated kinases mTOR, ERK, PKD, the MEF2 adaptor HDAC5 and the Ca2+ dynamics regulator phospholamban (PLN) [34]. This evidence concerns the gene PLN and cardiac hypertrophy.