In parallel, HE exhibits pronounced anti-inflammatory activity, inhibiting nuclear factor kappa B (NF-κB) activation and suppressing the production of pro-inflammatory cytokines, including IL-1β, IL-6, and interferon-gamma (IFN-γ), while simultaneously enhancing the expression of anti-inflammatory mediators such as interleukin-10 (IL-10). Here, IL10 is linked to hereditary elliptocytosis.