CNR2 and cancer: In this approach, the CB2-targeted cannabinoid mbc94 is covalently linked to a phthalocyanine photosensitizer through a ROS-cleavable linker, such that light irradiation simultaneously induces photodynamic cytotoxicity and irreversible release of the cannabinoid drug, producing potent antitumor effects in CB2R-overexpressing cancer cells.