NFKB1 and brain injury: Moreover, recent work in intestinal inflammatory disorders has highlighted a tight bidirectional crosstalk between barrier integrity and inflammatory signaling, whereby a disruption of junctional proteins activates NF-κB, further amplifying inflammation and barrier breakdown; although described in the intestinal epithelium, this signaling axis is conserved and may be highly relevant to blood–brain barrier dysfunction after traumatic brain injury [33].