In type 2 diabetes (T2D), elevated arginase activity may worsen ischemic injury through red blood cells (RBCs), but the specific roles of arginase isoforms are unclear.<h4>Methods</h4>C57BL/6 and db/db mice were pretreated with <i>ARG1</i> or <i>ARG2</i> antisense oligonucleotides (ASO) for six weeks. The gene discussed is ARG1; the disease is type 2 diabetes mellitus.