<b>Results:</b> miR-122 was found to negatively regulate genes involved in lipid metabolism, insulin signaling, and inflammatory pathways, including <i>PPARGC1A</i>, <i>PPARA</i>, <i>LPL</i>, <i>TLR4</i>, and <i>HMGCR</i>, contributing to insulin resistance and liver dysfunction. The gene discussed is TLR4; the disease is Insulin resistance.