BCL2 and B-cell chronic lymphocytic leukemia: These events included a rare double-IGH rearrangement involving IGH::BCL11A and IGH::BCL3 (S10; Figure 3A–C), a rare IGL::BCL2 t(18;22) with gain of chromosome 12 (S37; Figure 3D–F), and an IGH::BCL2 t(14;18) rearrangement (S45), which has been reported in approximately 1–2% of CLL cases overall [16].