Although t(14;18)(IGH::BCL2) is characteristic of follicular lymphoma and rarely seen in CLL/SLL, WHO recognizes it as a documented but uncommon exception; the two IGH::BCL2-positive, trisomy 12 cases in this cohort (S45, S48) fit this pattern and support their classification as true CLL with atypical cytogenetics. This evidence concerns the gene BCL2 and B-cell chronic lymphocytic leukemia.